Publications

Check out our recent publications!

  • A structural mechanism for noncanonical GPCR signal transduction in the Hedgehog pathway

    bioRxiv (2024)

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  • GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade

    PLOS Biology (2024)

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  • A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

    Nature Structural and Molecular Biology (2022)

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  • Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

    PLOS Biology (2021)

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  • Smoothened stimulation by membrane sterols drives Hedgehog pathway activation

    Nature (2019)

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Key Publications

  • A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway. bioRxiv (2024). William P. Steiner, Nathan Iverson, Varun Venkatakrishnan, Jian Wu, Tomasz Maciej Stepniewski, Zachary Michaelson*, Jan W. Bröckel, Ju-Fen Zhu, Jessica Bruystens, Annabel Lee, Isaac Nelson, Daniela Bertinetti, Corvin D. Arveseth, Gerald Tan, Paul Spaltenstein, Jiewei Xu, Ruth Hüttenhain, Michael Kay, Friedrich W. Herberg, Jana Selent, Ganesh S. Anand, Roland J. Dunbrack, Jr.#, Susan S. Taylor#, Benjamin R. Myers# pdf

  • A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma. Cell Reports (2024). Mattie J. Casey*, Priya P. Chan, Qing Li, Ju-Fen Zhu, Cicely A. Jette, Missia Kohler, Benjamin R. Myers, Rodney A. Stewart# pdf

  • GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade. PLOS Biology (2024). Madison F. Walker*, Jingyi Zhang*, William Steiner*, Pei-I Ku*, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Alyssa B. Long, Mattie J. Casey, Abhishek Poddar, Isaac B. Nelson, Corvin D. Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M. Kwan, Stefan Schulz, Rodney A. Stewart, John J. G. Tesmer, Tamara Caspary, Radhika Subramanian#, Xuecai Ge#, Benjamin R. Myers# pdf

  • A PKA Inhibitor Motif within SMOOTHENED Controls Hedgehog Signal Transduction. Nature Structural and Molecular Biology (2022). Happ, J.T.*, Arveseth, C.D.*, Bruystens, J.*, Bertinetti, D.*, Nelson, I.B.*, Olivieri, C.*, Zhang, J, Hedeen D.S., Zhu, J., Capener, J.L., Bröckel, J.W., Vu, L., King, C.C., Ruiz-Perez, V.L., Ge, X., Veglia, G., Herberg, F.W., Taylor, S.S.#, Myers, B.R.# pdf

  • Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits. PLOS Biology (2021). Arveseth, C. D.*, Happ, J. T.*, Hedeen, D. S., Zhu, J, Capener, J. L., Shaw, D. K., Deshpande, I., Liang, J., Xu, J., Stubben, S. L., Nelson, I. B., Walker, M. F., Krogan, N. J., Grunwald, D. J., Hüttenhain, R., Manglik, A., Myers, B. R. pdf

  • ​Smoothened Stimulation by Membrane Sterols Drives Hedgehog Pathway Activation. Nature (2019). Deshpande, I, Liang, J, Hedeen, D, Roberts, K.J., Zhang, Y, Ha, B, Latorraca, N.R., Faust, B, Dror, R.O., Beachy, P.A., Myers, B.R.#, Manglik, A.#  pdf ​

  • Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium. PNAS (2017). Myers, B. R.*#, Neahring, L.*, Zhang, Y., Roberts, K. R., Beachy, P. A.#  pdf

    • Commentary by Blassberg and Briscoe in Dev Cell: pdf

  • Identification of Recurrent SMO and BRAF Mutations in Ameloblastomas. Nature Genetics (2014). Sweeney, R.T.*, McClary, A.C.*, Myers, B.R.*, Biscocho, J.*, et al,  pdf

  • Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response.  Dev Cell  (2013). Myers, B. R., Sever, N., Chong, Y. C., Kim, J., Belani, J. D., Rychnovsky, S., Bazan, J. F., Beachy, P. A.  pdf

    • Commentary by Wang and McMahon in eLife: pdf

  • A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating. Neuron (2008). Myers, B. R., Bohlen, C., Julius, D. pdf

(* = first author; # = corresponding author)